KL1333 - CAS 1800405-30-4

KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD (P) H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.

Reductase, NADPH, Mitochondrial Metabolism

Metabolism, Endocrinology/Hormones

1800371

0.9989

C14H12N2O2

240.26

CC(C)c1nc-2c([nH]1)C(=O)C(=O)c1ccccc-21

-20°C

Ice Packs

Small Compound