KNa1.1-IN-2 - CAS 3037315-44-6

KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.

Potassium Channel

Membrane transporter/Ion channel

3037265

C24H27NO

345.48

O(C=1C=CC=2C=CC=CC2C1CCC3CCNCC3)CC=4C=CC=CC4

-20°C

Ice Packs

Small Compound