Kobe0065 - CAS 436133-68-5

Kobe0065 is a novel and effective small-molecule compound that inhibits the Ras-Raf interaction by structure-based drug design (SBDD) ; it displays potent activity, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.

Raf, Ras, Apoptosis

GPCR/G Protein, Apoptosis, MAPK

436060

>99.99%

C15H11ClF3N5O4S

449.79

Cc1ccc(NC(=S)NNc2c(cc(cc2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)cc1Cl

-20°C

Ice Packs

Small Compound