KRAS G12C inhibitor 47 - CAS 2253119-24-1

KRAS G12C inhibitor 47 is a potent inhibitor of KRAS G12C (IC50: 0.172 μM) . KRAS G12C inhibitor 47 exhibits p-ERK inhibition in MIA PaCA-2 cells, A549 cells with IC50 values of 0.046 μM and 69.8 μM respectively. KRAS G12C inhibitor 47 showed investigational potential against pancreatic, colorectal and lung cancers.

Others, Ras, Kras

Others, MAPK, GPCR/G Protein

2253119-24-1

C30H28ClFN4O3

547.02

O=C1N(C=2C(C(=N1)N3CCN(C(C=C)=O)CC3)=CC(Cl)=C(C2)C4=C(F)C=CC=C4O)C5=C(C(C)C)C=CC=C5

-20°C

Ice Packs

Small Compound