KRAS inhibitor-12 - CAS 2230874-00-5

KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 μM, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.

Ras, Kras, Others

GPCR/G Protein, MAPK, Others

2230874-00-5

C19H16Cl2FN5OS

452.33

FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(N)=N4

-20°C

Ice Packs

Small Compound