KRAS inhibitor-13 - CAS 2230873-96-6

KRAS inhibitor-13 (compound 5-6) is a potent inhibitor of KRAS G12C (IC50: 0.883 μM) and demonstrates a p-ERK inhibitory effect in MIA PaCA-2 and A549 cells with IC50 values of 5.9 μM and >100 μM respectively. KRAS inhibitor-13 has potential applications in pancreatic, colorectal, and lung cancer studies.

Ras, Kras, Others

GPCR/G Protein, MAPK, Others

2230771

C25H19ClFN3O2S

479.95

C(C=C)(=O)N1[C@@]2([C@@](N(C2)C3=C4C(=NS3)C(F)=C(C(Cl)=C4)C=5C6=C(C=C(O)C5)C=CC=C6)(CC1)[H])[H]

-20°C

Ice Packs

Small Compound