KRAS inhibitor-14 - CAS 2230873-78-4

KRAS inhibitor-14 is a potent inhibitor of KRAS G12C (IC50: 0.249 μM) . KRAS inhibitor-14 exhibited p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 1.12, >33.3 μM, respectively. KRAS inhibitor-14 has potential to be investigated in pancreatic, colorectal and lung cancers.

Ras, Others, Kras

GPCR/G Protein, Others, MAPK

2230791

C20H15Cl3FN3O2S

486.77

FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C(Cl)=CC(O)=C4

-20°C

Ice Packs

Small Compound