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KRAS inhibitor-15 - CAS 2230873-75-1

KRAS inhibitor-15 - CAS 2230873-75-1

MF-0006085-01

$1,927.85 USD
$1,391.00 USD $1,927.85 USD
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Product Details

  • Bioactivity

    KRAS inhibitor-15 (compound 3-19) is a potent inhibitor of KRAS G12C with an IC50 of 0.954 μM. It exhibits p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 2.03 μM and >33.3 μM, respectively. KRAS inhibitor-15 has potential for study in pancreatic, colorectal, and lung cancers.

  • Target

    Ras, Others, Kras

  • Related Pathways

    MAPK, GPCR/G Protein, Others

  • CAS Number

    2230873-75-1

  • Molecular Formula

    C20H17Cl2FN4OS

  • Molecular Weight

    451.34

  • SMILES

    FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(N)=C4

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound