KRAS inhibitor-16 - CAS 2230873-67-1

KRAS inhibitor-16 (compound 3-11) is a potent inhibitor of KRAS G12C (IC50: 0.457 μM) and exhibits p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 3.06 and 11.1 μM, respectively. KRAS inhibitor-16 has potential for study in pancreatic, colorectal, and lung cancers.

Others, Kras, Ras

GPCR/G Protein, Others, MAPK

2230805

C20H16Cl2FN3O2S

452.33

FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(O)=C4

-20°C

Ice Packs

Small Compound