KRAS inhibitor-17 - CAS 2230873-65-9

KRAS inhibitor-17 (compound 3-9) is a potent inhibitor of KRAS G12C with an IC50 of 3.37 μM. It exhibits p-ERK inhibition with an IC50 of 9.25 μM in MIA PaCA-2 cells and greater than 33.3 μM in A549 cells. KRAS inhibitor-17 has potential applications in the study of pancreatic, colorectal, and lung cancers.

Ras, Others, Kras

GPCR/G Protein, Others, MAPK

2230799

C21H18Cl2FN3O2S

466.36

FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=CC(OC)=CC=C4Cl

-20°C

Ice Packs

Small Compound