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KRAS inhibitor-18 - CAS 2230873-66-0

KRAS inhibitor-18 - CAS 2230873-66-0

MF-0020175-01

$1,383.80 USD
$988.00 USD $1,383.80 USD
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Product Details

  • Bioactivity

    KRAS inhibitor-18 (compound 3-10) is a potent inhibitor of KRAS G12C (IC50: 4.74 μM) and exhibited p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 66.4 μM and 11.1 μM, respectively. KRAS inhibitor-18 has potential for pancreatic, colorectal, and lung cancer studies.

  • Target

    Others, Kras, Ras

  • Related Pathways

    Others, GPCR/G Protein, MAPK

  • CAS Number

    2230873-66-0

  • Molecular Formula

    C20H15ClF3N3O2S

  • Molecular Weight

    453.87

  • SMILES

    FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(F)C=C(F)C(O)=C4

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound