KRAS inhibitor-27 - CAS 3033690-83-1

KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.

Ras, ERK, p38 MAPK

MAPK, GPCR/G Protein

3033606

C31H28ClF3N6O3S

657.106

N#CC1=C(SC2=C(F)C=CC(C=3C(F)=C4N=C(N=C5C4=C(OCC6N5CCCOC6)C3Cl)OCC78N(CCC7)CC(F)C8)=C12)N

-20°C

Ice Packs

Small Compound