KRAS inhibitor-3 - CAS 900897-56-5

KRAS inhibitor-3, an efficacious inhibitor of both wild-type (WT) and oncogenic KRAS mutations, exhibits high-affinity binding (K D: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, and 0.74 μM for KRAS Q61H) . Additionally, it impedes the interaction between KRAS and Raf, highlighting its potential as a targeted therapeutic agent in KRAS-mutant cancers.

Others, Kras, Ras

Others, MAPK, GPCR/G Protein

900836

C25H27N5O

413.51

Cc1nn2c(cc(nc2c1-c1ccccc1)-c1ccccc1)N1CCN(CCO)CC1

-20°C

Ice Packs

Small Compound