KRAS inhibitor-40 - CAS 3059496-56-6

KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.

Ras, PERK, Kras

GPCR/G Protein, Apoptosis, MAPK

3059434

C53H66ClF4N9O8S

1100.66

O=C1OCC(C)(C)CC=2C=3C=C(C=C4C3N(C2C5=CC(=CN=C5C(OC)C)N6CCOCC6)CC(F)(F)C4)C=7N=C(SC7)CC(NC(=O)C(N(C(=O)C8(F)CCN(C(=O)C(F)Cl)CC8)C)C(C)C)C(=O)N9NC1CCC9

-20°C

Ice Packs

Small Compound