KRASG12C IN-15 - CAS 2768868-14-8

KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.

ERK, Ras

MAPK, GPCR/G Protein

2768846

C31H32FN3O2

497.603

FC=1C(=C2C([C@]3(C(C)(C)[C@@](C2)(C3)[H])[H])=NC1N4CC5(CC4)CN(C(C=C)=O)C5)C=6C7=C(C=C(O)C6)C=CC=C7

-20°C

Ice Packs

Small Compound