KRASG12D-IN-5 - CAS 2933935-13-6

KRASG12D-IN-5 (Compound 241) is an orally active KRAS (G12D) inhibitor with an IC50 of 11 nM. It demonstrates potent anticancer activity without significant cytotoxicity to BxPC-3 cells (wild-type), KRAS-mutant AsPC-1 cells (G12D), and MIAPaCa-2 cells (G12C), with CC50 values of 10.37, 0.76, and 0.3 μM, respectively. KRASG12D-IN-5 is applicable in cancer studies, including lung, pancreatic, and colorectal cancers.

Ras

MAPK

2933916

C34H31F5N6O2

650.64

C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=C(O)C3)C=CC(F)=C4C#C)N5CC6(C(F)F)NC(C5)CC6)[C@@]78N(C[C@H](F)C7)CCC8

-20°C

Ice Packs

Small Compound