KRH-1636 - CAS 568526-77-2

KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR) 4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chemokine, stromal cell-derived factor 1alpha, to CXCR4 specifically and subsequent signal transduction. KRH-1636 prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor. KRH-1636 seems to be a promising agent for the treatment of HIV-1 infection.

Others, CXCR

Others, Immunology/Inflammation, GPCR/G Protein, Autophagy

568447

C32H37N7O2

551.68

[C@H](NC([C@@H](NC(=O)C1=CC=C(CNCC2=CC=CC=N2)C=C1)CCCNC(=N)N)=O)(C)C=3C4=C(C=CC3)C=CC=C4

-20°C

Ice Packs

Small Compound