KRN383 - CAS 919767-02-5

KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC (50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies.

Others, FLT

Others, Tyrosine Kinase/Adaptors, Angiogenesis

919767-02-5

C17H17N3O4

327.33

O(C=1C2=C(C=C(O)C(OC)=C2)N=CC1)C3CC=C(NC(N)=O)C=C3

-20°C

Ice Packs

Small Compound