KTX-582 - CAS 2573298-13-0

KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It effectively induces apoptosis in MYD88 MT DLBCL and has demonstrated efficacy in inducing in vivo tumor regressions in a lymphoma model [1] [2] [3].

IRAK, Apoptosis, PROTACs

NF-κB, PROTAC, Immunology/Inflammation, Apoptosis

2573285

C45H51F3N8O7

872.93

CN(CCCO[C@H]1C[C@@H](C1)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)C[C@H]1CC[C@@H](CC1)n1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C(C)(C)O

-20°C

Ice Packs

PROTAC