KU004 - CAS 1260401-93-1

KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.

Apoptosis, Akt, EGFR, ERK

MAPK, Angiogenesis, JAK/STAT signaling, Apoptosis, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors

1260401-93-1

C29H27ClFN4O2P

548.98

O=P1(C)CCN(CC#CC=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=C(F)C5)C(Cl)=C4)=C3C2)CC1

-20°C

Ice Packs

Small Compound