Kushenol I - CAS 99119-69-4

Kushenol I is a bioactive compound exhibiting anti-inflammatory, antioxidant, and ulcerative colitis–ameliorating effects, demonstrated in a DSS-induced UC mouse model where oral administration improved colon length, body weight, and disease scores while reducing pro-inflammatory cytokines including IL-1β, IL-6, IL-17, and TNF-α. Kushenol I increase IL-10 expression, inhibited key inflammatory signaling proteins such as AKT, p38 MAPK, PI3K, NLRP3, FOXO1, and TLR4, enhancing intestinal barrier integrity. Kushenol I positively modulate gut microbiota, and elevated splenic T-cell proportions, supporting therapeutic potential in inflammatory bowel disease.

TNF, NOD, FOXO, Akt, p38 MAPK, IL Receptor, TLR

Apoptosis, MAPK, Cytoskeletal Signaling, Immunology/Inflammation, PI3K/Akt/mTOR signaling, NF-κB

99046

0.9984

C26H30O7

454.51

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-20°C

Ice Packs

Natural Product