Kuwanon G - CAS 75629-19-5

1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.

ROS, PI3K, Apoptosis, Phosphatase, Glucosidase, Cholinesterase (ChE), NF-κB, Akt, Liver X Receptor, GSK-3, AChR, MMP, mTOR, Antibacterial, Bombesin Receptor

Neuroscience, Proteases/Proteasome, GPCR/G Protein, Immunology/Inflammation, Microbiology/Virology, NF-κB, PI3K/Akt/mTOR signaling, Metabolism, Stem Cells, Apoptosis, Cytoskeletal Signaling

75605

0.9957

C40H36O11

692.71

CC(C)=CCc1c(oc2c([C@H]3C=C(C)C[C@H]([C@@H]3C(=O)c3ccc(O)cc3O)c3ccc(O)cc3O)c(O)cc(O)c2c1=O)-c1ccc(O)cc1O

-20°C

Ice Packs

Natural Product