Kv7.2/Kv7.3 agonist 1 - CAS 2315450-35-0

Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.

Potassium Channel

Membrane transporter/Ion channel

2315415

C14H14FN3O2

275.28

O=C(NC1=NC(OCC2=CC=C(F)C=C2)=CC=C1N)C

-20°C

Ice Packs

Small Compound