KW-2449 - CAS 1000669-72-6

KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.

C-Kit, Aurora Kinase, JAK, Apoptosis, FLT, FGFR, Src, Bcr-Abl

Cell Cycle/Checkpoint, Angiogenesis, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Stem Cells, JAK/STAT signaling, Apoptosis

1000591

0.9989

C20H20N4O

332.4

O=C(N1CCNCC1)c1ccc(C=Cc2n[nH]c3ccccc23)cc1

-20°C

Ice Packs

Small Compound