KW-2450 free base - CAS 904899-25-8

KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.

Apoptosis, Aurora Kinase, IGF-1R

Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Apoptosis, Cell Cycle/Checkpoint

904866

0.9911

C28H29N5O3S

515.63

C(=C/C1=C(NC(=O)C=2SC=CC2C)C=C(CN3CCN(C(CO)=O)CC3)C=C1)\C=4C=5C(NN4)=CC=CC5

-20°C

Ice Packs

Small Compound