KY-05009 - CAS 1228280-29-2

KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity of Wnt target genes, and promotes apoptosis in cancer cells, displaying anti-cancer properties. Furthermore, it functions as an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM.

MAPK, Apoptosis, Wnt/beta-catenin

Cytoskeletal Signaling, Stem Cells, MAPK, Apoptosis

1228249

0.9989

C18H16N4O2S

352.41

Cc1ccc(cc1)C(=O)Nc1sc(Nc2ccccc2)nc1C(N)=O

-20°C

Ice Packs

Small Compound