KYL peptide - CAS 676657-00-4

KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM) ; inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM) . Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively) . Neuroprotective.

Ephrin Receptor

Tyrosine Kinase/Adaptors

676657-00-4

C74H108N14O17

1465.75

C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)CO)=O)CC(C)C)=O)[C@H](C)C)=O)CCC1)NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CCCCN)N)=O)=O)CC(C)C)=O)CCC2)CC4=CC=C(O)C=C4)=O)C=5C=6C(NC5)=CC=CC6

-20°C

Ice Packs

Peptide