L-2-Hydroxyglutaric acid - CAS 13095-48-2

L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH) . It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.

Histone Demethylase, Endogenous Metabolite, Mitochondrial Metabolism

Metabolism, Chromatin/Epigenetic

13045

C5H8O5

148.11

[C@H](CCC(O)=O)(C(O)=O)O

-20°C

Ice Packs

Natural Product