L002 - CAS 321695-57-2

L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension‐induced cardiac hypertrophy and fibrogenesis.

STAT, Epigenetic Reader Domain, Histone Acetyltransferase

JAK/STAT signaling, Stem Cells, Chromatin/Epigenetic

321636

0.9859

C15H15NO5S

321.35

COc1ccc(cc1)S(=O)(=O)ON=C1C=C(C)C(=O)C(C)=C1

-20°C

Ice Packs

Small Compound