LA-CB1 - CAS 3032908-44-1

LA-CB1 is a derivative of Abemaciclib that targets CDK4/6 and promotes their degradation via the ubiquitin-proteasome pathway, thereby blocking the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis (Apoptosis) . It demonstrates antiproliferative activity against MDA-MB-231 cells with an IC50 of 0.27 μM and effectively inhibits epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis. In highly invasive models like triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth, showing robust dose-dependent antitumor activity. This compound can be utilized in breast cancer research.

CDK, Apoptosis

Apoptosis, Cell Cycle/Checkpoint

3032863

C28H23ClFN7O

527.98

N#CC1=CC=CN=C1COC2=CC=C(C=C2Cl)NC=3N=CC=C(N3)C=4C=C(F)C=5N=C(N(C5C4)C(C)C)C

-20°C

Ice Packs

Small Compound