LAB687 - CAS 256397-11-2

LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.

MTP, Hedgehog/Smoothened, Smo

Metabolism, Stem Cells, GPCR/G Protein

256384

C26H23F3N2O3

468.47

C(NC=1C=C2C(=CC1)C[C@@H](NC(OC)=O)C2)(=O)C3=C(C(C)=CC=C3)C4=CC=C(C(F)(F)F)C=C4

-20°C

Ice Packs

Small Compound