Lactacystin - CAS 133343-34-7

Lactacystin is an orally active, irreversible, and cell-permeable proteasome inhibitor (IC50 = 4.8 μM) that also inhibits the lysosomal enzyme cathepsin A. It induces apoptosis and cell cycle arrest, possesses anticancer, antiviral, and antioxidant activities, can penetrate the blood-brain barrier, and is commonly used in the construction of Parkinson’s disease and dementia models.

Protease, Apoptosis, cAMP

GPCR/G Protein, Proteases/Proteasome, Apoptosis

133302

C15H24N2O7S

376.43

C(SC[C@H](NC(C)=O)C(O)=O)(=O)[C@@]1([C@H](C(C)C)O)[C@@H](O)[C@@H](C)C(=O)N1

-20°C

Ice Packs

Natural Product