Laduviglusib trihydrochloride - CAS 1782235-14-6

Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-3β with a Ki of 9.8 nM. Laduviglusib trihydrochloride is an activator of Wnt/β-catenin signaling. Laduviglusib trihydrochloride induces autophagy.

Autophagy, GSK-3, Wnt/beta-catenin

Cytoskeletal Signaling, Stem Cells, PI3K/Akt/mTOR signaling, Autophagy

1782215

0.9934

C22H20Cl5N8

573.71

Cl.Cl.Cl.Cc1cnc([nH]1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl

-20°C

Ice Packs

Small Compound