LBA-3 - CAS 2918263-09-7

LBA-3, a selective and orally active inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibits an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in both oleic and palmitic acid (OPA) -stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, as well as in mouse models, without showing detectable toxicity. Additionally, LBA-3 is permeable to the blood-brain barrier [1].

Sodium Channel

Membrane transporter/Ion channel

2918263-09-7

C18H18O5

314.33

C(CC(CC(O)=O)(C(O)=O)O)C1=CC=C(C=C1)C2=CC=CC=C2

-20°C

Ice Packs

Small Compound