LCL-PEG3-N3 - CAS 3033849-90-7

LCL-PEG3-N3 is a bait oligonucleotide E3 ligase ligand used for developing chimeric molecules like LCL-ER (dec) to degrade estrogen receptors. As a click chemistry reagent, it includes an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that possess DBCO or BCN groups.

E3 Ligase Ligand-Linker Conjugate

PROTAC

3033752

C32H45N7O6S

655.81

C([C@@H](NC([C@@H](NC)C)=O)[C@H]1CCCCC1)(=O)N2[C@@H](CCC2)C3=NC(C(=O)C4=CC(OCCOCCOCCN=[N+]=[N-])=CC=C4)=CS3

-20°C

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PROTAC