LCL-PEG3-N3 hydrochloride - CAS 3033849-91-8

LCL-PEG3-N3 (hydrochloride) serves as a bait oligonucleotide E3 ligase ligand, useful for developing chimeric molecules like LCL-ER (dec) to degrade estrogen receptors. As a click chemistry reagent featuring an Azide group, it can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

E3 Ligase Ligand-Linker Conjugate

PROTAC

3033750

C32H46ClN7O6S

692.27

C([C@@H](NC([C@@H](NC)C)=O)[C@H]1CCCCC1)(=O)N2[C@@H](CCC2)C3=NC(C(=O)C4=CC(OCCOCCOCCN=[N+]=[N-])=CC=C4)=CS3.Cl

-20°C

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PROTAC