LCRF-0004 - CAS 1229611-73-7

LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target.

Kras, Others, Ras, c-Met/HGFR

Tyrosine Kinase/Adaptors, Others, MAPK

1229531

C28H18F4N6O2S

578.54

O(C1=C2C(C=C(S2)C3=CN(C)C=N3)=NC=C1)C4=C(F)C=C(NC(=O)C5=C(C(F)(F)F)N(N=C5)C6=CC=CC=C6)C=C4

-20°C

Ice Packs

Small Compound