LE135 - CAS 155877-83-1

LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), showing higher affinity for RARβ. It is highly selective over RARγ, RXRα, RXRβ, and RXRγ. LE135 also acts as a potent TRPV1 and TRPA1 receptor activator with EC50s of 2.5 μM and 20 μM, respectively.

Retinoid Receptor, TRP/TRPV Channel

Membrane transporter/Ion channel, Metabolism

155793

0.9833

C29H30N2O2

438.56

CN1c2cc3c(cc2N=C(c2ccc(cc2)C(O)=O)c2ccccc12)C(C)(C)CCC3(C)C

-20°C

Ice Packs

Small Compound