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LEB-03-146 - CAS 2858812-91-4

LEB-03-146 - CAS 2858812-91-4

MF-0154699-01

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Product Details

  • Bioactivity

    LEB-03-146, a WEE1 DUBTAC (deubiquitinase-targeting chimera), effectively links AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a PEG2 linker. This compound demonstrates considerable WEE1 stabilization in HEP3B hepatoma cancer cells [1].

  • Target

    Wee1, Others

  • Related Pathways

    Others, Cell Cycle/Checkpoint

  • CAS Number

    2858717

  • Molecular Formula

    C46H57N11O8

  • Molecular Weight

    892.01

  • SMILES

    CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CCOCCOCCNC(=O)CCc4ccc(o4)N4CCN(CC4=O)C(=O)C=C)CC3)nc12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound