Lenalidomide 4'-alkyl-C3-azide - CAS 2399455-71-9

Lenalidomide 4'-alkyl-C3-azide (compound 4a), a chemically modified version of the orally active immunomodulator lenalidomide, is engineered for the synthesis of PROTACs. This compound, serving as a ligand for the ubiquitin E3 ligase cereblon (CRBN), integrates an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups [1].

Others, E3 Ligase Ligand-Linker Conjugate

Others, PROTAC

2399455-71-9

C16H18N6O3

342.35

N(CCCN=[N+]=[N-])C1=C2C(C(=O)N(C2)C3C(=O)NC(=O)CC3)=CC=C1

-20°C

Ice Packs

PROTAC