Lepadin E - CAS 444914-19-6

Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation while also augmenting ACSL4 expression, culminating in cell death. This compound exhibits a considerable antitumor effect [1].

Glutathione Peroxidase, MDM-2/p53, Ferroptosis

Apoptosis, Metabolism

444889

C26H47NO3

421.66

C(CCC[C@@H](CCC)O)[C@@H]1[C@]2([C@](N[C@@H](C)[C@H](OC(/C=C/CCCCC)=O)C2)(CCC1)[H])[H]

-20°C

Ice Packs

Small Compound