Leptomycin A - CAS 87081-36-5

Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins.

HIV Protease, CRM1, Antibiotic

Proteases/Proteasome, Microbiology/Virology, Membrane transporter/Ion channel

87040

C32H46O6

526.7

C[C@H](C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O)\C=C(\C)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C

-20°C

Ice Packs

Natural Product