LEQ-506 - CAS 1057677-92-5

LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh) -ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth.

Hedgehog/Smoothened, Others

GPCR/G Protein, Others, Stem Cells

1057580

C27H29N5O

439.55

C(C=1C2=C(C(=NN1)N3CCN(CC3)C4=CC=C(C(C)(C)O)C=N4)C=CC=C2)C5=CC=CC=C5

-20°C

Ice Packs

Small Compound