Lesogaberan napadisylate - CAS 477956-38-0

Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC50 of 8.6 nM for human recombinant GABA B receptors. It has an affinity (Ki) of 5.1 nM for rat GABA B receptors and 1.4 μM for GABA A receptors, determined by displacement of [3H]GABA binding in brain membranes. Lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation.

Others, GABA Receptor

Neuroscience, Others, Membrane transporter/Ion channel

477918

C13H17FNO5PS

349.31

NC[C@H](F)CP(O)=O.OS(=O)(=O)c1ccc2ccccc2c1

-20°C

Ice Packs

Small Compound