Lestaurtinib - CAS 111358-88-4

Lestaurtinib (CEP 701) is an orally available and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3, IC50: 0.9 nM), which inhibits FLT3 autophosphorylation in vitro.Lestaurtinib promotes the expression of c-MYC, inhibits the phosphorylation of RPTKs, and has high affinity for TrkA and JAK2. Lestaurtinib promotes c-MYC expression, inhibits phosphorylation of RPTKs, has a high affinity for TrkA and JAK2, induces apoptosis and cell growth arrest, and can be used to study leukemia.

Trk receptor, FLT, Apoptosis, JAK, STAT

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Apoptosis, Stem Cells, Chromatin/Epigenetic

111266

0.9917

C26H21N3O4

439.46

C[C@]12N3C=4C=5N(C=6C(C5C7=C(C4C=8C3=CC=CC8)CNC7=O)=CC=CC6)[C@](O1)(C[C@@]2(CO)O)[H]

-20°C

Ice Packs

Small Compound