Lexibulin - CAS 917111-44-5

Lexibulin (CYT-997) (CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines) . Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.

ROS, Microtubule Associated, Reactive Oxygen Species, Apoptosis

Metabolism, Cytoskeletal Signaling, NF-κB, Immunology/Inflammation, Apoptosis

917062

0.9922

C24H30N6O2

434.53

CCC[C@H](Nc1nc(ncc1C)-c1ccc(NC(=O)NCC)c(OC)c1)c1cccnc1

-20°C

Ice Packs

Small Compound