Lexibulin dihydrochloride - CAS 917111-49-0

Lexibulin 2Hcl is an effective tubulin polymerization inhibitor (IC50: 10-100 nM in cancer cell lines) . It also has potent cytotoxic and vascular disrupting activity in vitro and in vivo.

Apoptosis, Reactive Oxygen Species, Others, ROS, Microtubule Associated

Apoptosis, Metabolism, Immunology/Inflammation, Others, NF-κB, Cytoskeletal Signaling

917062

C24H32Cl2N6O2

507.46

COC1=C(NC(NCC)=O)C=CC(C2=NC=C(C)C(N[C@H](C3=CN=CC=C3)CCC)=N2)=C1.Cl.Cl

-20°C

Ice Packs

Small Compound