LG100268 - CAS 153559-76-3

LG100268 is a potent, selective, and orally active retinoid X receptor (RXR) agonist that agonizes RXR-α, RXR-β, and RXR-γ at the nanomolar level, selectively exceeding the RAR by three orders of magnitude.LG100268 is capable of inducing transcriptional activation in adipocytes; affecting the RXRs and their chaperone receptor, Foxl2/Dmrt1, to induce flounder masculinization in juvenile flounder; inhibits keratin 17 expression in nigrostriatal epithelial cells; and increases PD-L1 expression in HER2 or triple-negative breast cancer.

PD-1/PD-L1, Autophagy, Retinoid Receptor

Apoptosis, Cell Cycle/Checkpoint, Metabolism, Immunology/Inflammation, Autophagy

153480

0.9983

C24H29NO2

363.49

O=C(O)C1=CN=C(C=C1)C2(C=3C=C4C(=CC3C)C(C)(C)CCC4(C)C)CC2

-20°C

Ice Packs

Small Compound