LH1307 - CAS 2375720-38-8

LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays) .

Others, PD-1/PD-L1

Others, Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint

2375674

C54H58N8O6

915.108

CC(=O)NCCNCc1cc(C)c(OCc2cccc(c2C)-c2cccc(COc3cc(OCc4cncc(c4)C#N)c(CNCCNC(C)=O)cc3C)c2C)cc1OCc1cncc(c1)C#N

-20°C

Ice Packs

Small Compound