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Lifirafenib - CAS 1446090-79-4

Lifirafenib - CAS 1446090-79-4

MF-0013155-01

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Product Details

  • Bioactivity

    Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.

  • Target

    EGFR, Raf

  • Related Pathways

    MAPK, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

  • CAS Number

    1446007

  • Purity

    0.9825

  • Molecular Formula

    C25H17F3N4O3

  • Molecular Weight

    478.42

  • SMILES

    [H][C@]12Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@]1([H])[C@@H]2c1nc2ccc(cc2[nH]1)C(F)(F)F

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound